Therefore, increasing the agitation speed will enhance convective transport and assist in the deaggregation of particles, resulting in an increase in dissolution rates. It has been shown before that since the flow agitation from the rotating basket is very limited, convection plays an important role as a dominant transport process (4. The increase in dissolution rate with increasing agitation speed for strip- films containing nanoparticles compared to strip- films containing microparticles is attributed to the higher surface area of the drug nanoparticles, which enabled a better contact per surface area with the dissolution medium. On the other hand, the increase in dissolution rate of strip- films containing GF nanoparticles by increasing the agitation speed is more pronounced. The dissolution extent was observed to be close to 1. The dissolution profiles for the basket apparatus using different agitation speeds are shown in Fig. 5 for both formulations.
Dissolution Testing Using the Basket Method. Using USP I and USP IV for Discriminating Dissolution Rates of Nano- and Microparticle- Loaded Pharmaceutical Strip- Films.
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